VDR is a gene which encodes for a vitamin D receptor protein. This protein regulates calcium absorption and bone growth. A variant of the gene called rs2228570 (FokI polymorphism), is associated with a decrease in bone mineral density in white prepubertal girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated by the reciprocal and temporal pattern of off- and on- occupancy of the VDRE by the two components, and is modulated by chromosomal positions and binding preferences for specific hormones. Studies of microarrays in human cells reveal that more than 100 genes contain VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual dataroom (VDR) is a repository of data and documents relevant to legal transactions, business or procedures. Access to the data, downloading, or printing are not permitted. It utilizes a central server and an extranet connection, which is an Internet connection that has restricted access, to provide restricted access to log-in for specific intervals during which users can browse the documents and data.
Investment bankers and companies involved in mergers and acquisitions are among the most frequent users of VDRs. VDR. They require an efficient and secure platform to share information with potential buyers or investors in a clear and transparent manner, and the process of due diligence could require huge amounts of information. Life science companies also use VDRs to store everything from clinical trial results to HIPAA documentation.